155 papers
Developmental biology explores the incredible journey of how a single cell transforms into a complex, living organism. This field investigates the molecular switches and cellular conversations that guide growth, tissue formation, and the emergence of unique body structures, helping us understand both the origins of life and the roots of developmental disorders.
At Gist.Science, we ensure you never miss a breakthrough by processing every new preprint in this category from bioRxiv. Our team provides both plain-language explanations and detailed technical summaries for each paper, making cutting-edge research accessible to everyone regardless of their scientific background.
Below are the latest studies in developmental biology, offering fresh insights into how life takes shape.
This study integrates single-cell analysis and machine learning to identify seven ac4C-related prognostic genes in laryngeal squamous cell carcinoma that modulate the tumor immune microenvironment and serve as potential therapeutic targets.
This study employs chromatic persistence, a topological data analysis tool, to characterize the spatial organization and progressive entanglement of ductal, neuronal, and vascular networks during pancreatic development, revealing distinct timelines for loop formation and a concentration of network threading toward the organ's interior.
This study identifies ZNHIT1 as a critical chromatin remodeler that ensures successful male meiosis by facilitating H2A.Z deposition, which cooperates with the transcription factor A-MYB to regulate pachytene gene expression and enable proper homologous recombination.
This paper introduces FuChi, a novel transgenic chicken line equipped with an optimized multicistronic Fucci biosensor that enables precise, real-time tracking of all cell cycle phases in live embryos, thereby revealing critical proliferation dynamics during avian development and establishing a superior in vivo model for studying cell-cycle kinetics.
This study presents a cross-species single-cell transcriptomic atlas of sheep and other eutherian mammals that reveals conserved signaling pathways and species-specific variations in symmetry breaking, establishing sheep as a vital model for understanding human peri-implantation development.
This study demonstrates that while cone photoreceptor ablation in microglia-deficient larval zebrafish triggers a compensatory immune response and only modestly affects Müller glia proliferation and cone regeneration, the presence of these alternative immune cells limits definitive conclusions about microglia's specific role in retinal regeneration.
This study demonstrates that zebrafish can gradually overcome a heritable defect in intestinal protein absorption through recurrent, genome-wide transcriptional changes that hyperactivate endocytic components in specialized enterocytes while simultaneously recalibrating immune responses to ensure survival despite protein malnutrition.
This study identifies the embryonic fourth ventricle choroid plexus as the earliest brain circadian oscillator, emerging before the suprachiasmatic nucleus and utilizing specific bifurcation dynamics to couple with maternal rhythms during development.
This study reveals that the tissue composition at the axolotl amputation plane dictates distinct skeletal integration strategies by triggering osteoclast-mediated resorption specifically in calcified regions through the upregulation of RANKL and Ccl24-like, thereby ensuring seamless regeneration regardless of the injury site.
This study establishes a conserved regulatory network in human and Xenopus cardiogenesis where the transcription factor GATA4 directly activates TBX2 and represses PRDM1 to ensure proper cardiomyocyte differentiation, prevent alternative cell fates, and maintain functional cardiac structure.