274 papers
This study identifies a conserved phospho-switch at SALL4 residue T903, which integrates BMP4-DUSP9 signaling to regulate BAF complex interaction and cell fate determination, where its disruption leads to failed reprogramming and severe cranial developmental defects in mice.
This study presents the first comprehensive single-cell transcriptomic map of the Xenopus laevis mesonephros, revealing conserved nephron patterning and differentiation mechanisms that link this aquatic kidney form to mammalian metanephric development.
This study reveals that adult Drosophila females require adipocyte-derived amino acid storage proteins (Lsp1 and Lsp2) to maintain germline stem cells by activating TOR signaling, a process that operates independently of the reabsorption proteins Fbp1 and Fbp2 in ovarian follicle cells.
This study establishes a reproducible *in vitro* protocol using human serum that enables schistosomes to progress beyond early developmental stages, digest red blood cells, and achieve sexual dimorphism, thereby overcoming previous limitations in studying their sexual biology and facilitating the 3Rs in animal research.
This study reveals that the transcription factor Weckle acts as a molecular switch in Toll signaling, diverting the pathway from innate immunity to promote glial cell growth and structural brain plasticity by facilitating the nuclear translocation of the growth regulator Yorkie.
This study utilizes a novel multimodal imaging framework to reveal a previously unrecognized, stage-dependent mineralization signature in the enamel, dentin, and alveolar bone of a TBCK syndrome mouse model, demonstrating that combining techniques beyond conventional microCT is essential for detecting early craniofacial defects in this genetic disorder.
This study presents a semi-supervised workflow to reconstruct high-resolution 3D spatial transcriptomic models of the adult planarian *Schmidtea mediterranea*, revealing the organism's cellular architecture, identifying 119 positional control genes, and characterizing the stem cell microenvironment to advance our understanding of tissue organization and regeneration.
This study utilizes the developing chick embryo to map the conserved molecular features and dynamic spatiotemporal organization of distinct tubulin isotypes during corneal morphogenesis, establishing a comprehensive resource for understanding cytoskeletal regulation in eye development.
This study demonstrates that planarian regeneration relies on a non-specific stem cell response where injury triggers broad amplification and spatial redistribution of progenitors rather than tailoring cell production to the specific identity of missing tissues, resulting in a mechanism that restores missing parts through imprecise but effective wound-associated amplification.
This paper establishes standardized laboratory husbandry protocols for the Indian stick insect (*Carausius morosus*), detailing optimal environmental conditions, dietary requirements, and care methods for eggs and hatchlings to facilitate its use as a reproducible model system for scientific research.
This study identifies and characterizes a novel, reversible form of suspended animation in *C. elegans* induced by high population density in liquid, revealing that it involves extensive molecular and cellular remodeling while being regulated by endo-lysosomal pathways for survival and a neuronal axis for awakening.
This study identifies PKN, a rapidly evolving female-specific transmembrane protein in brown algae, as a critical determinant of sex- and species-specific fertilization that enforces reproductive isolation by mediating male-female gamete recognition.
This study demonstrates that constant light rearing accelerates the development and alters the ultrastructure of the larval zebrafish olfactory epithelium, including the loss of microvillar receptor cells and the presence of mitotic figures, indicating that environmental light levels significantly impact the timing of sensory system growth and receptor replacement.
This study utilizes zebrafish models to demonstrate that complement signaling acts as a sex-specific modifier of idiopathic scoliosis severity, with C3 upregulation exacerbating curves in females and C5 loss worsening them in males, thereby linking innate immunity to the disease's sex bias.
This study utilizes in situ mutational screening and CRISPR interference to identify specific transcription factors and a critical HOX binding site within the *apterous* early enhancer that are essential for establishing the dorsal/ventral compartment boundary and preventing anterior wing duplications during *Drosophila* development.
This study reveals that the lipid-shielding protein Shifted/DmWif1 facilitates Hedgehog morphogen dispersal by anchoring to the co-receptor Ihog on cytoneme membranes, thereby enabling direct cell-to-cell transfer of Hh at contact sites and unifying cytoneme-mediated transport with membrane release mechanisms.
This study demonstrates that the Drosophila ryanodine receptor (dRyR) is essential for both muscle contractility and structural development, and validates its utility as a model system for assessing the pathogenicity of human RYR1 variants, such as the p.Met4881Ile mutation.
This study demonstrates that while sub-optimal paternal diets (including high-fat, low-protein, and methyl-supplemented variations) do not significantly impair male fertility in mice, they induce sex-specific alterations in fetal growth, placental gene expression, and the reduction of sexually dimorphic genes, thereby programming offspring development through mechanisms involving metabolic and Wnt signaling pathways.
This study characterizes the C. elegans protein ZFH-2, a conserved zinc finger-homeodomain transcription factor, as being continuously essential for the structural integrity and function of the alimentary tract and gonad, while revealing that its critical activity relies on a subset of its homeodomains despite broad nervous system expression.
This study reveals that in zebrafish, YAP signaling regulates a long-range feedback mechanism coupling posterior progenitor addition with anterior vacuolation to ensure robust notochord elongation, a balance that is disrupted in *vgll4b* mutants by excessive progenitor recruitment and impaired cell expansion.